Effect of Eubacterium limosum on health?
A special bacterium in the gut seems to reduce the risk for heart disease. The bacterium reduces the production of a substance that is related to the development of clogged arteries in combination.
In a recent investigation of the Ohio State University, it was found that the bacterium Eubacterium limosum reduces the likelihood for diseases of the heart. The results were published in the English journal “the Journal of Biological Chemistry”.
Production of trimethylamine was reduced
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The researchers studied how the activity of the bacterium Eubacterium limosum has an impact on the risk for heart disease. They found that this bacteria in the intestine reduces the production of a special substance called trimethylamine, which has already been brought before the development of clogged arteries in combination. After this fabric was produced in the intestine, it passes into the bloodstream and to the liver, where it finally, in its most pernicious Form is converted.
Competition from bacteria in the gut
The behavior of the investigated bacterium seems to be on a family of proteins can be due. It shows how certain gut organisms beneficial for the human health can be. In Essence, these healthy microbes compete with unhealthy bacteria to have access to the same nutrients in the intestine. If the healthy bacteria will prevail, you can prevent health problems that can result from the way the body food is metabolized.
Eubacterium limosum soothes inflammation in the gut
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The research group explained that she sees a potential in the case of Eubacterium limosum for future use for therapeutic purposes. Previous studies have already shown that the bacterium is healthy, because it calms inflammation in the intestine.
Bacteria in the gut affect the health significantly
“In the last decade has shown that bacteria affect in the human gut our health in many ways. The organism that we have studied, affects the health, by preventing a problematic connection to a worse will,” says the study’s author, Professor Joseph Krzycki, the Ohio State University in a press release.
How is trimethyl amine?
The with clogged arteries-related substance, which is for atherosclerosis characteristic is referred to as trimethylamine, or TMA. TMA is produced during metabolism, when some of the intestine act on microbes with specific nutrients from the food interactions. One of these nutrients is L-carnitine, a compound which occurs naturally in meat and fish and also as a dietary Supplement to support the recovery after the Sport is used.
What is the role of a Protein called MtcB?
The research group found that E. limosum in the intestine acts in a special manner with L-carnitine to the role of L-carnitine in the production of TMA turns off. However, there are also other nutrients which are also involved in TMA production in the gut. The researchers attribute the positive health effects of the bacteria on a Protein called MtcB. This enzyme cuts off certain molecules from Compounds to help bacteria, to produce energy and to survive.
The toxicity of TMA is reduced
The above-described process is referred to as demethylation and also includes the removal of a methyl group (a carbon atom surrounded by three hydrogen atoms) to modify the structure or function of a connection. The bacterium does this to his own advantage, with the result that it reduces the toxicity of TMA.
Bildungung harmful Compounds prevent?
The research group comes to the conclusion that that bacteria can remove a methyl group, to form other harmful Compounds. In the case of the interaction of L-carnitine acts as a growth substrate, is a compound that is consumed, so that the organism can live and grow. In addition, it also acts as a target for the enzyme activity, explain the researchers.
Intestinal bacteria need to be better explored
For the study of E. limosum-cultures were fed with a range of potential substrates, including L-carnitine. Only if L was offered carnitine, synthesized by the microbe, the MtcB-Protein, the methyl group of L-cut carnitine. In Essence, MtcB is part of the natural processes, such as the bacteria consume the nutrient. The significant health Benefits in the case of a type of gut bacteria shows that there is still much to learn about how bacteria in the human metabolism, and can affect health, the researchers say.
Further research is needed
“MtcB is part of a family of proteins with Thousands of representatives, which can use different Connections and change, which bacteria help to consume the nutrients in the intestine. These proteins may behave chemically very similar, but the use of different Compounds can obviously result in major changes in biology,” adds Professor Krzycki. Further research in this area is already in the planning stage. (as)
