3.36London

Friday, 29 November 2024

Novel ADC Offers Hope in Heavily Pretreated NSCLC

SINGAPORE — Heavily pretreated patients with EGFR-mutated non–small cell lung cancer (NSCLC) may experience a clinically meaningful benefit with the antibody-drug conjugate (ADC) patritumab deruxtecan (HER3-DXd), new phase 2 trial results suggest. In the trial, almost 30% of patients receiving HER3-DXd achieved an objective response, and patients’ median overall survival…

DR MARTIN SCURR: Simple steps to help ward off sight-loss as you age

DR MARTIN SCURR: Simple steps to help ward off sight-loss as you age After developing dry eyes six months ago, I had an eye test and was told I’m at risk of macular degeneration in five years.  I’m an active 71-year-old and run, sew and do crosswords every day. I…

Alzheimer's: MS drug shows promise as potential treatment

Millions of people globally have Alzheimer’s disease, for which there is currently no cure. A great deal of research has been focusing on new therapies for the condition. In a study on human brain cells and mouse models of Alzheimer’s, scientists at the University of Kentucky College of Medicine have…

Is Additional Treatment Needed Pretransplant in R/R AML?

HOUSTON ― Should patients with acute myeloid leukemia (AML) for whom induction therapy fails to induce complete remission proceed to allogeneic hematopoietic stem cell transplant anyway? Or do these patients fare better when they receive an intensive salvage induction regimen to bring them into remission before transplant? This critically important…

Alzheimer's: Could a two-step test improve diagnostic accuracy?

Alzheimer’s disease, a neurodegenerative condition that causes memory impairment, was the focus of a new study published by Swedish researchers. The researchers designed a two-step disease detection process that may aid in reducing unnecessary invasive testing related to Alzheimer’s disease. The researchers believe this process could improve diagnostic accuracy and…

Increasing severe maternal morbidity linked to heat exposure

Research led by the University of California at Irvine provides strong evidence linking maternal heat exposure during pregnancy to an increased risk of severe maternal morbidity, with potential implications for public health strategies and interventions. In a paper, “Analysis of Heat Exposure During Pregnancy and Severe Maternal Morbidity,” published in…

Revealed: The factors that could leave YOU at risk of cancer

Revealed: The factors that could leave YOU at risk of cancer – as number of preventable cases in UK to hit 184,000 this year As many as four in 10 cases of cancer are preventable by leading a healthy life Cutting down on cigarettes and alcohol can help prevent several…

Unlocking the secrets of our body's first line of defense against strep throat and more

In a recent study posted to the bioRxiv* preprint server, researchers determined the cryogenic-electron microscopic (cryo-EM) structures of secretory immunoglobulin A (sIgA)-M4 and sigA-CD89 complexes. Study: The Structures of Secretory IgA in complex with Streptococcus pyogenes M4 and human CD89 provide insights on mucosal host-pathogen interactions. Image Credit: Corona Borealis Studio / Shutterstock.com *Important notice: bioRxiv publishes…