Cumulative lifetime excess weight has a greater impact on colorectal cancer (CRC) risk than excess weight at a single time point, according to a study published online March 17 in JAMA Oncology.
Xiangwei Li, from the German Cancer Research Center in Heidelberg, and colleagues examined the association of cumulative lifetime excess weight with the risk for CRC in a population-based, case-control study. Height and self-reported weight were documented in 10-year increments starting at age 20 years to current age for 5,635 individuals with CRC and 4,515 controls. Body mass index (BMI) was calculated for each year of age from 20 years to current age. At each year of age, excess BMI (eBMI) was determined as BMI − 25 and was summed across ages to obtain the weighted number of years lived with overweight or obesity (WYOs).
The researchers observed an association between WYOs and CRC risk: Compared with individuals who remained within the normal weight range, the adjusted odds ratios increased from 1.25 to 2.54 from the first to the fourth quartile of WYOs. The risk for CRC increased 55 percent for each standard deviation increment in WYOs (adjusted odds ratio, 1.55). This increase was greater than the per-standard deviation increase of eBMI at a single time point.
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