Trial questions benefits of organic nitrates for bone health

Several clinical trials have reported beneficial effects of organic nitrates on bone health, which could lead to a reduced risk of fractures. Some of these trials have been retracted because of scientific misconduct; however. A new study published in the Journal of Bone and Mineral Research found that organic nitrates do not have clinically relevant effects on bone mineral density or bone turnover in postmenopausal women, and the medications caused significant side effects.

The study was a double-blind, randomized, placebo-controlled trial of three different nitrate preparations and two different doses in postmenopausal women with bone loss. There were no differences in changes in bone mineral density or bone turnover markers between organic nitrate treatment and placebo.

The results call into question the validity of previous clinical research reporting large positive effects of nitrates on bone health.

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